Melanotan II
MelanocortinLast reviewed: September 26, 2026 by Vina Peptides Team
A tanning peptide for deep skin darkening and libido enhancement.
A synthetic melanocortin receptor agonist studied for its potential effects on pigmentation and metabolic pathways in laboratory research.
Mechanism:Melanotan II is researched for its potential to activate melanocortin receptors involved in pigmentation and metabolic signaling in research models.
Type
Tanning Peptide
Length
7 amino acids (heptapeptide)
Format
Lyophilized powder
Use
Research only
Core BenefitsKey Advantages
Deep tan
Stimulates melanin production for a deep, natural-looking tan without extensive sun exposure.
Reduced sunburn
Increased melanin may provide some natural protection against UV damage.
Libido enhancement
Known to increase sexual desire in both men and women.
Faster tanning
Achieves a tan with much less sun exposure than normally required.
Long-lasting tan
The tan from Melanotan II tends to last longer than a natural tan.
Appetite suppression
Some users report reduced appetite as a side effect.
These are educational summaries of commonly discussed effects, not guarantees.
Results TimelineProgression
| Phase | Physical Changes | Performance & Recovery | Other Benefits |
|---|---|---|---|
| Week 1-2 | Early skin darkening, slight tan development | N/A (cosmetic focus) | Possible libido increase, reduced appetite |
| Week 3-4 | Noticeable tan, darker skin tone | N/A | Increased libido, continued appetite suppression |
| Month 2-3 | Deep, rich tan with minimal sun exposure | N/A | Sustained libido enhancement |
| 3+ Months | Maintained deep tan | N/A | Long-lasting tanning and libido effects |
Timeline is illustrative and non-guaranteed. Outcomes vary and depend on training, nutrition, sleep, and cycling practices.
Research Overview
Outcome-by-outcome look at what the evidence actually supports for Melanotan II, including human vs. animal study counts and our editorial take on each.
Tanning (melanin production)
Melanotan II was originally developed for tanning. Clinical trials confirm it stimulates melanin production and darkens skin.
5 human studies · 10 animal studies
Sources for this data
Our Take
The tanning effect is well-documented. The peptide does what it claims for skin darkening.
Libido enhancement
Studies show Melanotan II increases sexual desire and erectile function in both men and women. A related drug (bremelanotide) is FDA-approved for female sexual dysfunction.
8 human studies · 12 animal studies
Sources for this data
Our Take
The libido effects are well-documented. Bremelanotide (a derivative) is an approved drug.
Sun protection
Increased melanin provides some UV protection, but Melanotan II is not a substitute for sunscreen.
1 human studies · 5 animal studies
Sources for this data
Our Take
Some natural protection from increased melanin, but it's not reliable sun protection.
What Melanotan II doesn't do
Claims that current evidence does not support. Worth knowing before you set expectations.
Replace sunscreen
Increased melanin provides minimal UV protection. You still need sunscreen to prevent skin damage and cancer risk.
Tan without any UV exposure
Melanotan II stimulates melanin production, but some UV exposure (or tanning beds) enhances the effect. It doesn't fully tan without sun.
Work without side effects
Melanotan II is known for side effects including nausea, flushing, moles darkening, and potential melanoma risk. It's not a mild peptide.
Dosing ProtocolProtocol
Educational reference only. Individual responses vary. Consult healthcare provider before use.
Vial Size
10 mg
Reconstitution
2 ml BAC water
Dose
Start 250 mcg, titrate to 500-1000 mcg
Timing
PM (before bed to reduce nausea)
Frequency
Daily during loading, then 1-2x per week for maintenance
Duration
2-3 weeks loading, ongoing maintenance
Protocol Notes
Start with a low dose to assess tolerance. Common side effects include nausea, flushing, and darkening of existing moles. Monitor moles closely. Do not use if you have a history of melanoma.
Reconstitution Calculator
Concentration
2.50 mg/mL
2500 mcg/mL
Volume to Draw
10.0 units
0.100 mL
Doses per Vial
20
For laboratory research use only. Based on a 1 mL (100-unit) insulin syringe.
Recommended Vendor
Vina Bio Labs
For research-grade Melanotan II with verified Certificates of Analysis, we recommend Vina Bio Labs — our affiliated research peptide supplier.
Storage & Handling
Storage at a glance
Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
Handling specifics
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
Powder storage — very stable
- • Freezer (-20°C): 1+ year
- • Refrigerator (2-8°C): 1-3 months
- • Room temperature: 2-3 weeks (emergency only)
Reconstituted — fragile
- • MUST refrigerate at 2-8°C
- • 4-week maximum shelf life
- • NEVER freeze after reconstitution
- • Use bacteriostatic water for multi-dose
Frequently Asked Questions
How does Melanotan II work?
Melanotan II stimulates melanocortin receptors, which increases melanin production (tanning) and can enhance libido. It mimics the body's natural tanning response.
Do I still need sun exposure?
Some UV exposure enhances the tanning effect, but much less than normally needed. Melanotan II doesn't fully tan without any sun exposure.
What are the side effects?
Common side effects include nausea, flushing, darkened moles and freckles, and increased libido. More serious concerns include potential melanoma risk. Start with a low dose.
Is Melanotan II safe?
Melanotan II is not FDA-approved and carries significant risks, including skin cancer concerns. It should only be used for research purposes. Monitor your skin closely.
Sources & References
Melanotan II and melanogenesis: a pharmacological review
Melanocortin receptors and their role in skin pigmentation
Melanotan II safety and adverse effects: a clinical review
Sources are provided for research and educational reference. Inclusion does not imply endorsement of any product or use.
For laboratory research use only. Content is provided for research and educational purposes only and is not intended for human consumption, medical use, or diagnostic applications.